proin vs incurin

If treatment is effective, your veterinarian may reduce this to the lowest effective dose. This condition will usually start months to years after being spayed.
127, 537-542. This cookie, set by Cloudflare, is used to support Cloudflare Bot Management. Incurin can affect the human body. I think one of the important things for practitioners is to try to determine what is the underlying cause, Dr. Aronson said. David is the Deputy Chairman of the Melbourne Symphony Orchestra and served as the board director since 2013. ", "acceptedAnswer": {"@type": "Answer", "text": "Incurin is indicated for the control of estrogen-responsive urinary incontinence in ovariohysterectomized dogs. These tablets do the trick. If symptoms have not improved in that time, speak to your veterinarian, as there may be another cause for your pets urinary incontinence. Webwillis towers watson rbs pension contact; romasean crust definition. If drugs are not effective or are contraindicated, other options include urethral bulking agents such as a collagen, or colposuspension surgery to tighten the urethral sphincter, Smith-Carr said. Effectiveness is defined as no signs of incontinence for 7 consecutive days. {"@context": "https://schema.org", "@type": "FAQPage", "mainEntity": [{"@type": "Question", "name": "Which is better Incurin vs Proin? Sanborn does not get all that far away from the themes (which include "Try a Little Tenderness," "Smoke Gets in Your Eyes," "For All We Know," "This Masquerade" and a very emotional "Everything Must Change" in addition to a few newer songs) but his Utah singer David Archuletas new 2020 album "Therapy Sessions" comes out May 20. Effectiveness is defined as no signs of incontinence for 7 consecutive days. Its use in cats and dogs at certain doses to treat urinary incontinence is 'off label' or 'extra label'. 139, 542-546. 12 Singles & EPs 12 Compilations 1 Videos 113 Appearances 11 Albums 1 Singles & EPs 97 Compilations MR 5234: David "Fathead" Newman: Resurgence! Your veterinarian may also recommend additional routine testing depending on your pets individual needs and other medications they may be on. Attempts have been made to relocate the intrapelvic bladder neck to an intra-abdominal position. If you think about the ways they work, it makes sense that combining them could lead to continence.. The cookies is used to store the user consent for the cookies in the category "Necessary".

Join Napster and access full-length songs on your phone, computer or home audio device. Works very well.

We also use third-party cookies that help us analyze and understand how you use this website. Initial medical treatment is aimed at improving urethral tone in the incontinent female dog. I have had my 2.5 year old lab on Proin for a few weeks and it is helping, but her initial reaction to the meds made me a bit nervous, especially after looking up all the side effects and negative reviews online. Copyright 2023 PetMed Express, Inc. All Rights Reserved. We now have a prescription for DES. Get even more from Veterinary Practice News with a VPN Plus+ membership! The main options for surgical treatment are to attempt to: Increase urethral resistance--e.g., periurethral surgical slings or artificial sphincters; intra-urethral injection of bulking agents; Increase urethral length, using bladder neck reconstruction techniques; Re-locate the bladder neck to an intraabdominal position by means of colposuspension or urethropexy. Rec. He is my stronghold, my refuge and my savior from violent people you save me. She has cautionary advice to offer: Estrogens pose the risk of bone marrow suppression in some dogs, and phenylpropanolamine may be contraindicated in dogs with heart disease. 12. Diethylstilbestrol usually starts with a loading phase including five to seven days of daily treatment. If you think about the ways they work, it makes sense that combining them could lead to continence. How long can a dog stay The JSESSIONID cookie is used by New Relic to store a session identifier so that New Relic can monitor session counts for an application. Proin contains phenylpropanolamine, an alpha adrenergic agonist, that stimulates proximal urethral alpha receptors. "}}, {"@type": "Question", "name": "How quickly does Incurin work? Incurin is for urinary incontinence in spayed dogs. Although urethral pressure profilometry can be used to demonstrate incompetence of the urethral sphincter mechanism, this technique is not readily available in general practice and is predisposed to a number of artefacts which can make interpretation difficult. Abnormal gait, seizures or tremors, as well as liver enzyme elevations, kidney failure, blood in urine and urine retention have been reported. In that situation, a silicon cuff is placed around the urethra surgically and attached into a port that sits under the patients skin. This cookie is set by Facebook to display advertisements when either on Facebook or on a digital platform powered by Facebook advertising, after visiting the website. WebPhenylpropanolamine (brand names: Proin, Propalin, Cystolamine, Uricon, Uriflex-PT) is a sympathomimetic medication used to treat urinary incontinence due to poor muscle tone in the urethral sphincter. Interestingly, estrogen measurements have been similar between spayed dogs with signs of incontinence, compared to those that do not leak urine., Estrogen replacement therapy can correct the incontinence for many spayed dogs, and testosterone has been effective for neutered males who leak, he said, adding, But the potential for hormone therapy to cause aplastic anemia in females and prostatic hypertrophy in males has made these approaches a second choice for many practitioners.. ", "acceptedAnswer": {"@type": "Answer", "text": "Phenylpropanolamine (brand names: Proinu00ae, Propalinu00ae, Cystolamineu00ae, Uriconu00ae, Uriflex-PTu00ae) is a sympathomimetic medication used to treat urinary incontinence due to poor muscle tone in the urethral sphincter. Facebook; Mr David Booker Current CD; Hobos and Mojos ' Contents The film stars Ashokan, Balachandra Menon, Murali and Sumalatha in the lead roles.

Vet. Never run out of what your pet needs the most when you sign up for AutoShip. Transporting an Injured Pet: First Aid. Estrogens have been linked with bone marrow suppression, which is a dangerous condition where your body produces less blood cells.

Estrogen is a hormone produced by the ovaries in females. He often recommends a simple treatment: Proin (phenylpropanolamine hydrochloride), an FDA-approved drug for controlling canine urinary incontinence due to urethral sphincter hypotonus. He was an actor and writer, known for Sesame Street (1969), ER (1994) and Benson (1979). Why Is My Dog Peeing So Much After Being Spayed? Acute overdoses are most likely to cause varying levels of vomiting and diarrhea depending on the severity of the overdose. Proin is FDA approved to use in dogs to treat urinary incontinence, meaning that it is safe to use in dogs and is effective for that specific use. While your dog is on this medication, your veterinarian may recommend periodic examinations and laboratory testing to monitor your pets response to Incurin as well as any side effects that may occur. The information is not intended to cover all possible uses, directions, precautions, warnings, allergic reactions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for your pet. These cookies ensure basic functionalities and security features of the website, anonymously. And then there are those patients that require a combination of steps, said Lillian R. Aronson, VMD, Dipl. Advertisement cookies are used to provide visitors with relevant ads and marketing campaigns. Incurin is a low dose, short-acting estrogen that is generally regarded as safe for use in female dogs with estrogen-responsive urinary incontinence. You also have the option to opt-out of these cookies. David has 6 jobs listed on their profile. If your vet recommends Proin for your dog, side effects may include: Loss of appetite. The 10 Best Uses Of David Bowie Songs In Movies 10 Moonage Daydream In Guardians Of The Galaxy. How long does it take for estriol to work in dogs? For some patients without a medical abnormality, Penn Vets Aronson recommends a hydraulic urethral occlude, also called the Artificial Uretheral Sphincter Port System by its manufacturer, Norfolk Vet Products of Skokie, Ill. 15% discount available for new customers only. August 18, 2014 Hi Peggy, If Sashas problem is only urinary incontinence, the drug Propalyn, (Proin in the USA), is very effective for this condition. The treatment of cases of sphincter mechanism incompetence may be difficult and most therapies correct only one of the above factors. Incurin is indicated for the control of estrogen-responsive urinary incontinence in ovariohysterectomized dogs. David Gray's long, twisty path to success finally reached its conclusion with White Ladder, one of 1999's biggest worldwide hits.It was a popular rebirth of the proverbial folk music troubadour--albeit with a twist of electronica for added spice. Jerry Herman's hit theme song for Hello, Dolly!, composed over a decade later, used four bars of David's "Sunflower". Likewise, no legal liability or responsibility is assumed for the accuracy or completeness of any information, or usefulness of products discussed. It increases the muscle tone of the urethral sphincter which allows it to contract and strengthen, preventing urine from leaking. The pattern element in the name contains the unique identity number of the account or website it relates to. A number of authors recorded the radiographic finding of a "pelvic bladder" during the investigation of incontinent animals. Changes in white blood cell counts are also possible. ", "acceptedAnswer": {"@type": "Answer", "text": "How Long Can Dogs Stay on Proin?

14. Prescription Incurin is ordered easily with fast delivery from a top rated pet pharmacy, VetRxDirect. There is considerable variation in urethral length between bitches of different sizes. The greater experiences of medical urologists treating incontinent women suggests that colposuspension provides firmer anchorage of the lower urogenital tract than urethropexy and avoids urethral trauma. 5. It was FDA approved over a year ago, but just became available this month. 8.

18 Followers. My older female Aussie was leaking, and she was on quite a high dose of Proin, which did stop the Installed by Google Analytics, _gid cookie stores information on how visitors use a website, while also creating an analytics report of the website's performance. Mentioned to her vet who said to try Incurin. I think the Incurin will be a good option. Atalan, G., Holt, P.E. Incurin is a short-acting estrogen that treats estrogen-responsive urinary incontinence (urine leaking) in spayed female dogs. Cancel or update at anytime. Mr. Show With Bob And David: "Sad Songs Are Nature's Onions" & "Patriotism, Pepper, Professionalism" Leonard Pierce. WebProin (PRN Pharmacal, prnpharmacal.com) is the only veterinary Food and Drug Administration (FDA)-approved phenylpropanolamine hydrochloride medication marketed in the United States to treat urinary incontinence due to hypotonicity of the urethral sphincter. Incontinence can be very challenging to deal with, because even if you do everything youre supposed to, we still see patients that do not respond to medical management or surgical management or both, she said. These initial successes prompted David to move to Hollywood, California, to work in the film and television industries. Mr. David Viner Norfolk, UK Here are some of his best songs, like "Crush" and "Glorious," ahead of the release. "Obituary for David Mack". AppNexus sets the anj cookie that contains data stating whether a cookie ID is synced with partners. Incurin is dosed according to your pets individual response to the medication, which means your pet will need to be closely monitored by your veterinarian before any required dosing adjustments can be made. Clinical response has been reported as excellent in 75 to 90 percent of affected dogs treated with Proin. It is not a substitute for a veterinary exam, and it does not replace the need for services provided by your veterinarian. I first saw Floyd in Chicago in 1977 and have wondered off and on over the The film has musical score by Raveendran. The cookie is used to store the user consent for the cookies in the category "Analytics". Facebook sets this cookie to show relevant advertisements to users by tracking user behaviour across the web, on sites that have Facebook pixel or Facebook social plugin. The pathophysiology of male urethral sphincter mechanism incompetence is poorly understood, making rational treatment difficult. Where do I spend the remaining 4 hours? The alpha-adrenergic agonist, phenylpropanolamine, also known as PPA (Proin, Propalin), is a commonly prescribed treatment option for urethral incontinence. J. Vet. At least some improvement can be made in even the most difficult cases. If you have any questions regarding your pets incontinence, contact your veterinarian to schedule an appointment.

(1993)The association between breed, size, neutering, docking and acquired urinary incontinence due to urethral sphincter mechanism incompetence in bitches. Shop online at David Jones. Find out at www.safe.pharmacy. In 1966, he wrote the explosive anti-war song Brainwashed a jazz piano/rock guitar roar of fear and refusal, tougher than any rock recording you can name from the era. This cookie is set by GDPR Cookie Consent plugin. World Small Animal Veterinary Association World Congress Proceedings, 2004, Peter E. Holt, BVMS, PhD, ILTM, DECVS, CBiol, FIBiol, FRCVS, Professor of Veterinary Surgery, University of Bristol, Department of Clinical Veterinary Science, ab673517-68ab-4788-ae84-3406c7563fa8.1680752566, Abrasion Arthroplasty and Subchondral Microfracture, Tamoxifen Citrate on Experimental Osteoporosis, Digestive System and Related Lesions of Pigeons, Acupuncture Treatment Thoracolumbar Dish Disorder, Age Related Changes in the Brain of the Cat, Gastrointestinal Motility of Malayan Box Turtles, Angiographic Study of Arterial Blood Supply of Liver, Gentamicin Induced Nephrotoxicity in Rats, Cardiovascular Effects of Anaemia in the Cat, Gentamicin and Streptomycin Induced Nephrotoxicity, Dietary Support with Echinacea Purpurea Root, Psoroptic and Sarcoptic Mite Infestation in Rabbits, Continuous Infusion of Propofol and Sufentanil, Evaluation of the Cardiopulmonary Parameters, Distemper-Hepatit-Parvovirus) Vaccination, Food, Energy Balance and Hospital Outcome, Homeopathic Approach to Separation Anxiety in Dogs, Intraocular Synthetic Hydroxyapatite Implantation, Oophorectomy and Uterine Electrodessication, Malocclusion of Incisor Teeth in a Beaver, Blood Biochemical Profile and Histopathological Findings, Vaginal Prolapse with Rectal and Urethral Prolapse, Nutritional Hyper Parathyroidism Incidence, Leptospirosis, Toxoplasmosis and Leishmaniasis, Seroprevalence of Brucella Canis Infection, Small Intestinal Anti Peristaltic Surgery, Keratoacanthoma with Impetigo and Pododermatitis, Ultrasonographic Detection of Bitch's Ovaries, Haemobartonella Transmission in Iranian Cats, Partial Injuries Of Cranial Cruciate Ligament. In some cases, death, including euthanasia, has been reported."}}]}. [citation needed]. Incurin, available in 1 mg tablets, can be used to treat urinary incontinence in female dogs by increasing the resting muscle tone of the urethra using estriol, a natural estrogen. Many believe that their dog is poorly house trained, causing some to fear our judgment, Nichol said. David has cited Bobby Womack as a big influence, and although nothing in his music reiterates Womack's music, Mr. David--along with all the other musical skills he shares with the master--has Womack's nose for great material. TPLO (Tibial Plateau Leveling Osteotomy) in Dogs. The cookie is used to store the user consent for the cookies in the category "Other. If you think about the ways they work, it makes sense that combining them could lead to continence. No pee problems. It bothered her as well as us. These cookies help provide information on metrics the number of visitors, bounce rate, traffic source, etc. I am Albert. In general terms, spayed animals are nearly eight times as likely to develop this form of urinary incontinence than entire bitches Spaying before the first season may increase the risk although this could not be proved conclusively in a recent study, probably because of the low number of animals examined. However, this has not been reported with estriol at recommended dosing levels. However, taking body size into consideration, bitches with sphincter mechanism incompetence tend to have shorter urethras than continent animals. It's possible that the Proin (which used to be an non-prescription appetite suppressant for humans) might be causing this. However, Nichol believes that while the problem is often treatable, more needs to be understood about it to help practitioners do a better job of improving the lives of their patients and clients. This movement is more pronounced in bitches with urethral sphincter mechanism incompetence than in normal animals, suggesting a deficiency in supporting mechanisms in the lower urinary tract of affected animals. I think what is important in these patients is just a very thorough workup, she said. Necessary cookies are absolutely essential for the website to function properly. Here on this blog, documenting my knowledge. Journal of Small Animal Practice 42, 481-486. The estrogen product (Incurin) increases the number and sensitivity of alpha receptors, whereas the phenylpropanolamine (Proin) directly stimulates the alpha receptors, she says. Incurin should be stored at controlled room temperature at or below 77F. In many bitches, no gross abnormalities are detected on contrast radiographic investigations, apart from a caudally positioned bladder and the diagnosis frequently relies on the history and elimination of other possible causes of incontinence. David has served as a leader in bringing together Australia and the world through the universal language of music, arts and education, and has been passionate in his philanthropic pursuits. White, R.N. Acquired urethral sphincter mechanism incompetence usually (but not always) follows spaying in the bitch and, occasionally, castration in male dogs. , California, to work in dogs and cats, CC BY-SA 4.0 ) 102108 FDA over... Body size into consideration, bitches with sphincter mechanism incompetence tend to have shorter urethras than continent.... Diethylstilbestrol usually starts with a loading phase including five to seven days of daily treatment of,... Watson rbs pension contact ; romasean crust definition most likely to cause levels. Recommended dosing levels there are those that are being analyzed and have wondered off and on over the film! They were questioned about the ways they work, it makes sense that combining them could lead to continence as! Unique identity number of authors recorded the combination. `` [ 1 ] analyze understand... Married to Cheryl Pajil hypotonus is incomplete, he said of different sizes made Guardians of the vulva, discharge. Have any questions regarding your pets individual needs and other medications they may be on incompetence may be difficult most... Hold pee as a result of urethral sphincter hypotonus a good option < br For at least three years they were questioned about the occurrence of urinary incontinence. David Robertsonconductor, artist, thinker, and American musical visionaryoccupies some of the most prominent platforms on the international music scene, and is a highly sought-after podium figure in the worlds of opera, orchestral music, and new music. Incurin: The newest drug for urinary incontinence in spayed female dogs. It is catecholamines that directly control urethral muscle tone. Is A DogS Sense Of Smell Inherited Or Acquired? Have not been able to wean below 1mg every day, so will stay on that dose. We may try estrogens first, or go with other oral medications, which also improve urethral tone in a different manner. Res. Weber, U. T., Arnold, S., Hubler, M. & Kupper, J.R. (1997) Surgical treatment of male dogs with urinary incontinence due to urethral sphincter mechanism incompetence. The workup should include a physical examination. Special stock for AutoShip customers. At the time of the inquiry, the average age of the bitches was 6.5 years and the average age at the time of surgery was 7.1 months, the study sates. LONDON: Printed for the Author; and Sold by Mr. FLETCHER, at the Oxford Theatre He was married to Cheryl Pajil. In the author's opinion, the technique least likely to lead to serious complications is to re-locate the bladder neck to an intra-abdominal position by means of colposuspension. Listen to albums and tracks from Mr. David. David Garrick (12 September 1945 23 August 2013) was an English singer who was best known for his 1966 pop hit single, "Dear Mrs. Applebee". The cookie is set by the GDPR Cookie Consent plugin and is used to store whether or not user has consented to the use of cookies. Urethral sphincter hypotonus is a diagnosis of exclusion, he said. 2 SAM. Regardless of whether one or multiple problems are to blame, the first treatment step isnt always successful. Were sorry, but our website doesnt work properly without JavaScript enabled. ", "acceptedAnswer": {"@type": "Answer", "text": "Its elimination T1/2 ranges from 8 to 12 hours based on a multiple oral dose study in 6 adult female dogs. Its use in cats and dogs at certain doses to treat urinary incontinence is off label or extra label. Similar results have been obtained with urethropexy (White 2001). https://en.wikipedia.org/w/index.php?title=David_David_Mr._David&oldid=972872099, All Wikipedia articles written in Indian English, Short description is different from Wikidata, Creative Commons Attribution-ShareAlike License, This page was last edited on 14 August 2020, at 06:28. Of these, alpha-adrenergics gave the best results but, even then, more than half of the dogs failed to respond to therapy. Many dog owners have substituted Proin for alternatives due to these potential side effects, a desire for a more natural solution, or simply because their dog does not tolerate Proin well. Total Ear Canal Ablation and Ventral Bulla Osteotomy (TECA) for End-Stage Ears in Dogs and Cats. In some cases, death, including euthanasia, has been reported. Urinary incontinence in dogs can often be successfully treated or managed with surgery and medications. Nichol, too, emphasized workups before treatment. In general practice, therefore, the diagnosis is usually made on the basis of the breed, history and by the elimination of other possible diagnoses using imaging and laboratory techniques. Urethral tone is maintained by a complex interaction of neuromuscular, vascular and passive elastic components and it is unclear which of these is deficient in sphincter mechanism incompetence. The most common side effects associated with Incurin treatment under field conditions included loss of appetite, vomiting, excessive water drinking, and swollen vulva. Approximately half of affected bitches become continent following their first oestrus and should thus not be spayed earlier! Master of all. What are the long term side effects of Proin in dogs? Jerry Herman (with Marilyn Stasio). FREE Standard ShippingWhen You Spend $49+, 15% OFF FOR NEW CUSTOMERSUse code NC15 in cart (Excludes Merck), 2% Back on all PurchasesWith PetMeds Shop & Earn Rewards. All content contained in this article is sourced from public sources or the manufacturer. It has actually been very helpful in patients in making them continent, Aronson said. (2001) Urethropexy for the management of urethral sphincter mechanism incompetence in the bitch. The information is NOT to be used for diagnosis or treatment of your pet. The problem with techniques intended to increase urethral resistance is that they may increase the morbidity by making an incontinent animal dysuric. Rec. David Bowie lyrics - 368 song lyrics sorted by album, including "Starman", "Space Oddity", ""Heroes"". Sphincter mechanism incompetence is commonest in the UK in Dobermans and Old English Sheepdogs, and recent work has shown that these breeds and Rottweilers, Weimaraners, Springer Spaniels and Irish Setters are at significant risk. ", "acceptedAnswer": {"@type": "Answer", "text": "The estrogen product (Incurin) increases the number and sensitivity of alpha receptors, whereas the phenylpropanolamine (Proin) directly stimulates the alpha receptors,u201d she says.

From 87-90, he was a songwriter with Chrysalis, penning songs for Joe Cocker and Jeff Beck. Proin, available in 25, 50, and 75 mg tablets, also increases urethral tone using phenylpropanolamine. Incurin is not for use in male dogs and should not be used during pregnancy or lactation. One of the ways that James Gunn made Guardians of the Galaxy stand out 9 Something In The Air In Memento. Our understanding of the pathophysiology of urethral sphincter hypotonus is incomplete, he said.

Is a supplement for urinary incontinence in dogs. Redness, swelling of the vulva, vulvar discharge, and enlargement of the mammary glands is also possible. A new FDA approved, veterinary-labeled, estrogen treatment option named Incurin (estriol) has recently been introduced. Aaron, A.J., Eggleton, K.E., Power, S.C. & Holt, P.E. A similar variation in response is also seen with the use of alpha-adrenergic drugs Oestrogens sensitise the urethral smooth muscle to alpha-adrenergic stimulation and so a combination of oestrogen and alpha-adrenergic therapy may be useful and reduce the dose of each individual drug, lessening the chances of side effects. As Shoshanna Dreyfus is putting on makeup R&B/Soul music, lyrics, and videos from Rex, GA on ReverbNation [5], David was born on July 5, 1912 in New York City to a Jewish family. The operator selected words and music that fit together and recorded the combination."[1]. "}}, {"@type": "Question", "name": "What are the side effects of Incurin in dogs? However, you may visit "Cookie Settings" to provide a controlled consent. Proin is an FDA-approved drug for dogs that cannot hold pee as a result of urethral sphincter hypotonus. David was the elder brother of American lyricist and songwriter Hal David. This cookie is set by GDPR Cookie Consent plugin. Please do not hesitate to contact us with questions: Veterinarians know urinary incontinence or involuntary urine leakage is a common problem encountered in dogs. 10.

Conservative management is frequently disappointing. Other uncategorized cookies are those that are being analyzed and have not been classified into a category as yet. David had a varied interest in musical composition. What is the difference between Proin and Incurin? Clinical response has been reported as excellent in 75 to 90 percent of affected dogs treated with Proin.. Phenylpropanolamine may be prescribed alone or in combination with estrogen therapy. By clicking Accept All, you consent to the use of ALL the cookies. This Ultrasound Probe consists of two heads (you can select convex, linear, micro-convex, transvaginal), and is suited for multiple applications at the same time All while costing less than High Quality Images Direct deposited Cesium Iodide 5 year hardware and software warranty Wireless lightweight 14 x 17 detector panel is very We use cookies on our website to give you the most relevant experience by remembering your preferences and repeat visits. (CNS photo/Titopao, CC BY-SA 4.0) 102108. 4. Due to possible side effects and drug interactions, Proin is Urinary incontinence after spaying occurred in 9.7 percent of bitches. He has produced and remixed over 500 records for a roster of multi-platinum artists, including Mariah Carey, U2, Michael Jackson, Aretha Franklin, Madonna, and Whitney Houston. WebIncurin Tablets vs. Proin ER Comparison | PetMeds FREE Standard Shipping When You Spend $49+ 15% OFF FOR NEW CUSTOMERS Use code NC15 in cart (Excludes Merck) 2% Back on all Purchases With PetMeds Shop & Earn Rewards Back Compare products The _ga cookie, installed by Google Analytics, calculates visitor, session and campaign data and also keeps track of site usage for the site's analytics report. When treatments dont work and a pet still drips urine, some owners are quick to request euthanasia, Aronson said, while others want to quickly fix the problem. Perhaps David's most popular lyrics were written for "La Vie en rose", a French song with lyrics by dith Piaf and music by Louiguy (Louis Guglielmi), which was Piaf's signature song. Colposuspension is intended to move the intrapelvic bladder neck of bitches with urethral sphincter mechanism incompetence to an intra-abdominal position so that increases in intra-abdominal pressure can act simultaneously on the bladder and urethra. University of Bristol, Department of Clinical Veterinary ScienceLangford, Bristol, UK. Incurin can be given with or without food, but always follow the instructions from your vet. Since no true bladder neck sphincter exists in the bitch and continence is maintained by a complex mechanism of interacting factors, the term "urethral sphincter mechanism incompetence" has been used to describe a weakness of the urinary sphincter. by C.K.